心肌酶谱和肌钙蛋白I联合检测对诊断急性心肌梗死的临床应用价值(1)
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[摘要] 目的:探讨心肌酶谱和肌钙蛋白I联合检测在急性心肌梗死早期诊断的临床应用价值。方法:对2009年1月～2010年1月本院就诊的205例就诊的急性胸痛患者同时联合检测心肌酶谱(AST、LDH、CK、CK-MB、HBDH、Mg2+)和肌钙蛋白I(cTnI),比较其检测结果对于诊断急性心肌梗死的特异性和灵敏性。结果:205例就诊的急性胸痛患者中经确诊120例为急性心肌梗死,其中103例心肌酶谱升高,敏感性为85.8%,112例肌钙蛋白I阳性,敏感性为93.3%。120例阴性对照中,10例心肌酶谱升高,特异性为91.7%,5例肌钙蛋白I阳性,特异性为95.8%。结论:心肌钙蛋白I与心肌酶谱的联合应用提高了临床对AMI诊断的及时性和准确性。
[关键词] 心肌酶谱;肌钙蛋白I;急性心肌梗死
[中图分类号] R542.2 [文献标识码]A [文章编号]1674-4721(2010)04(c)-038-02
Diagnostic value of cardiac enzymes and troponin I combination detection in acute myocardial infarction
LIANG Wei1*,YI Weilian2
(1.Department of Clinical Laboratory, the Port People's Hospital, Zhanjiang 524008, China;2.Department of Clinical Laboratory,the Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001, China)
[Abstract] Objective: To explore the clinical value of cardiac enzymes and troponin I combination detection in the diagnosis of acute myocardial infarction (AMI). Methods: Gather 205 cases of acute chest pain patients from January 2009 to January 2010, at while take its blood into be measured the cardiac enzymes (AST, LDH, CK, CK-MB, HBDH, Mg2+) and troponin I (cTnI) levels, compared their specificity and sensitivity for the diagnosis of acute myocardial infarction. Results: In 205 acute chest pain patients, 120 patients confirmed to acute myocardial infarction, 103 patients of cardiac enzymes rise, the sensitivity was 85.8%, Troponin I was positive in 112 patients, the sensitivity was 93.3%. Among 120 cases negative control, 10 cases of cardiac enzymes rised, the specificity was 91.7%, 5 cases of troponin I was positive, the specificity was 95.8%. Conclusion: Troponin and cardiac enzymes combination detection improved the accuracy of clinical diagnosis of AMI.
[Key words] Myocardial enzymes; Troponin I;Acute myocardial infarction
急性心肌梗死(AMI)是临床常见的急性多发病,正确诊断及时救治对挽救濒死心肌,改善预后降低急性期病死率和死亡率具有重要意义。但在急诊条件下,心电图有时缺乏特异性改变,而冠状动脉造影技术尚不能普及开展,因此寻找一种快速检测手段成为必要。为此笔者对205例急性胸痛患者进行了联合检测,以评价早期诊断急性心肌梗死的临床应用价值。
1 资料与方法
1.1 一般资料
205例急性胸痛患者,胸痛持续时间1～9 h,平均时间4.6 h, 其中,男107例,女98例,年龄24～83岁,平均51 ......
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